Simple Polyphenyl Zirconium and Hafnium Metallocene Room-Temperature Lumophores for Cell Imaging

Zirconium
and hafnium metallocene dihalides based on simple polyphenyl
cyclopentadienes are stable room-temperature lumophores with large
Stokes shifts, emitting from states with substantial LMCT character.
Their synthesis is described, including by a rapid solvent-free approach
compatible with the lifetime of PET-active isotopes (89Zr). Preliminary experiments indicate the viability of these species
as lumophores for fluorescence cell-imaging microscopy.

基于简单聚苯基环戊二烯的二卤化锆茂金属与二卤化铪茂金属是一类稳定的室温发光体，具有较大的斯托克斯位移（Stokes shift），其发射态具备显著的配体到金属电荷转移（Ligand-to-Metal Charge Transfer, LMCT）特征。本研究报道了该类化合物的合成策略，其中包括一种可适配正电子发射断层显像（Positron Emission Tomography, PET）活性同位素（89Zr）半衰期的快速无溶剂合成路径。初步实验结果表明，这类化合物作为荧光细胞成像显微镜用发光体具备实际应用可行性。