Characterization of liver-pancreas crosstalk following beta-cell loss reveals a role for the molybdenum cofactor in beta-cell regeneration

Understanding beta-cell regeneration and how inter-organ communication can contribute to that is crucial for developing new approaches for diabetes treatment. With this dataste we characterized the hepatocyte beta-cell axis and how it can contribute to beta-cell regeneration in a zebrafish model of beta-cell loss. This data provide a transcriptomics analysis of isolated hepatocytes following beta-cell ablation.

阐明β细胞（beta-cell）再生机制以及器官间通讯如何参与该过程，对于开发糖尿病治疗新策略至关重要。本数据集针对β细胞缺失的斑马鱼模型，系统表征了肝细胞- β细胞轴及其在β细胞再生中的调控作用；同时收录了β细胞消融后分离得到的肝细胞的转录组学（transcriptomics）分析数据。