PRDX6 and SLC6A9: Key Molecular Players in Intracerebral Hemorrhage - Induced White Matter Lesions

ICH - related WML has complex molecular mechanisms. By using MR and scRNA - seq, we explored PRDX6 and SLC6A9. MR identified PRDX6 as high - risk and SLC6A9 as low - risk genes. ScRNA - seq verified their cell - specific expression in brain tissues. PRDX6 was in dendritic and NK/T cells, SLC6A9 in microglia. Functional analyses showed their roles in different pathways. Our study reveals important molecular regulators for ICH - induced WML.与脑出血（Intracerebral Hemorrhage, ICH）相关的脑白质病变（White Matter Lesions, WML）具有复杂的分子机制。本研究借助磁共振成像（Magnetic Resonance Imaging, MR）与单细胞RNA测序（single-cell RNA sequencing, scRNA-seq）技术，对PRDX6与SLC6A9两个基因展开探究。磁共振成像分析将PRDX6鉴定为高危基因，SLC6A9为低危基因。单细胞RNA测序验证了二者在脑组织中的细胞特异性表达：PRDX6表达于树突状细胞与NK/T细胞，SLC6A9则表达于小胶质细胞。功能分析显示二者在不同通路中发挥作用，本研究揭示了脑出血诱导的脑白质病变中重要的分子调控因子。