Additional file 7: of Strong correlation of downregulated genes related to synaptic transmission and mitochondria in post-mortem autism cerebral cortex

Table S5. Differential expression analysis between autism and control cerebral cortex in the Voineagu et al. dataset. Table of differential expression analysis between autism and control cerebral cortex in the Voineagu et al. dataset, adjusted for RIN, PMI, age, sex, and cortical location (temporal vs. frontal). The analysis was performed using the Bioconductor package limma and adjusted for multiple testing using the Benjamini-Hochberg method. Because several individuals were included twice (for both frontal and temporal cortexes) in this analysis, the analysis was also redone limiting samples only to frontal or temporal cortex. Note that the p values in the cortex-specific analyses are not adjusted for multiple testing. (XLSX 265 kb)

表S5：Voineagu等人数据集内自闭症患者与对照人群大脑皮层的差异表达分析。本表格收录Voineagu等人数据集内自闭症患者与对照人群大脑皮层的差异表达分析结果，已针对RNA完整性数（RNA Integrity Number, RIN）、死后间隔时间（Postmortem Interval, PMI）、年龄、性别以及皮层脑区（颞叶与额叶）进行协变量校正。本次分析采用Bioconductor工具包limma完成，并通过Benjamini-Hochberg法实施多重检验校正。鉴于本次分析中部分受试者被重复纳入（分别对应额叶与颞叶皮层样本），我们额外重新开展了仅限定单一皮层脑区（仅额叶或仅颞叶）样本的分析。需注意，皮层特异性分析中的P值未进行多重检验校正。（XLSX格式，265 KB）