Text S1 - Autonomous Targeting of Infectious Superspreaders Using Engineered Transmissible Therapies

Full description of the multi-scale model used to predict the effects of a TIP intervention on HIV-1 infection dynamics among a population of host individuals, within host individuals, and within host cells. This report contains detailed descriptions of each model, tables of parameters and state variables, supporting figures, an analysis of the sensitivity of the TIP model to changes in parameters, and an analysis of the sensitivity of the TIP model to changes in structure and changes in basic transmission biology. (PDF)