Text S1 - Autonomous Targeting of Infectious Superspreaders Using Engineered Transmissible Therapies

Full description of the multi-scale model used to predict the effects of a TIP intervention on HIV-1 infection dynamics among a population of host individuals, within host individuals, and within host cells. This report contains detailed descriptions of each model, tables of parameters and state variables, supporting figures, an analysis of the sensitivity of the TIP model to changes in parameters, and an analysis of the sensitivity of the TIP model to changes in structure and changes in basic transmission biology. (PDF)本数据集完整描述了一款用于预测TIP干预对宿主个体种群、宿主体内及宿主细胞内人类免疫缺陷病毒1型（HIV-1）感染动态影响的多尺度模型。本报告包含各模型的详细说明、参数与状态变量表、配套辅助图表，以及TIP模型针对参数变化、结构变更与基础传播生物学特性变化的敏感性分析。（PDF格式）