Whole-exome sequencing analysis of six pairs of HCC primary tumors and matched adjacent tissues

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Understanding of the mutation profiles of HCC is instructive for developing personalized therapy and molecular biomarkers. We performed six pairs of HCC primary tumors and matched adjacent tissues to identify the key somatic mutant genes.

肝细胞癌（Hepatocellular carcinoma，HCC）是全球范围内最常见的恶性肿瘤之一。对该肿瘤突变谱的深入认知，可为个性化治疗方案与分子生物标志物的研发提供重要指导价值。本研究纳入6对肝细胞癌原发肿瘤及其配对癌旁组织，旨在鉴定关键体细胞突变基因。