Regioselective Synthesis of Indolizines, Pyrrolo[2,1-a]isoquinolines, and Quinolines

Convenient and regioselective synthesis of indolizine and pyrrolo[2,1-a]isoquinoline/quinoline derivatives by one-pot multicomponent reaction of N-substituted pyridinium and isoquinolinum/quinolinium salts with alkyl propiolates in the presence triphenylphosphine is described.

本研究报道了一种便捷且具备区域选择性的合成策略：以N-取代吡啶鎓盐、异喹啉鎓/喹啉鎓盐与炔丙酸烷基酯为原料，在三苯基膦作用下经一锅多组分反应，制备中氮茚及吡咯并[2,1-a]异喹啉/喹啉衍生物。