Shear-Responsive Nanotherapeutics for Targeted Thrombosis Prevention in Cardiovascular Models: From Microfluidic Validation to Clinical-Scale Applications

This research developed an innovative solution to prevent dangerous blood clots in heart devices and diseased blood vessels. The key innovation is a smart drug delivery system, tiny nanocapsules that release blood-thinning medicine only in spots where blood flows at dangerous high speeds, reducing bleeding risks elsewhere in the body. Starting with laboratory experiments in small devices that mimic blood vessels, the research successfully progressed to testing in full-sized heart-lung machines. The work also created improved designs for medical devices, making these life-saving devices safer for patients.