nsp3-4 cleaves itself

This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.<br><br>To process the nsp3/4 cleavage site, PL-PRO and, presumably, nsp3-4 need to be glycosylated and localized to a membrane (Harcourt et al, 2004).

本COVID-19事件系由对SARS-CoV-1数据的计算推断（参见https://reactome.org/documentation/inferred-events）与人工编纂相结合所创建，具体编纂过程可参阅SARS-CoV-2感染途径概述。针对nsp3/4切割位点，PL-PRO以及推测上的nsp3-4需进行糖基化并定位于细胞膜上（参见Harcourt等人，2004年）。