Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class

Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class Descriptor: 1-[(3~{R},4~{R})-4-(cyanomethyl)-3-fluoranyl-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide, Tyrosine-protein kinase JAK1 Authors: Brown, D.G, Lupardus, P.J. Deposit date: 2019-05-21 Release date: 2020-07-08 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class To Be Published氨基吡唑类JAK1-ATP结合口袋抑制剂的基于结构优化 化合物标识：1-[(3R,4R)-4-(氰甲基)-3-氟-1-[(4-联苯基)甲基]哌啶-4-基]-3-(环丙基羰基氨基)吡唑-4-甲酰胺，酪氨酸蛋白激酶JAK1 作者：Brown, D.G.、Lupardus, P.J. 入库日期：2019-05-21 发布日期：2020-07-08 最后修改日期：2024-10-23 测试方法：X射线衍射（分辨率1.71埃） 引用文献：氨基吡唑类JAK1-ATP结合口袋抑制剂的基于结构优化（待发表）