Estimates of the substitution rate and the tMRCA of HCV for the E2 gene with HVR1 by Bayesian coalescent methods, under several molecular clock and population genetic models.

aMarginal likelihoods were calculated via importance sampling using the harmonic mean of the sampled likelihoods (with the posterior as the importance distribution).
bTime of the most recent common ancestor. The numbers between brackets are the 95% lower and upper values from the highest posterior density (95%HPD).
cSubstitution rates are given in nucleotide substitutions per site per year (s/s/y). The numbers between brackets are the 95% lower and upper values from the highest posterior density (95%HPD).
***** = the model failed to converge.

a. 边际似然值（marginal likelihood）通过重要性抽样（importance sampling）计算得到，以采样所得似然值的调和均值作为估算结果，且以后验分布作为重要性分布。
b. 最近共同祖先时间。括号内的数值为95%最高后验密度（95%HPD）对应的置信下限与上限值。
c. 替换速率以核苷酸替换·位点⁻¹·年⁻¹（s/s/y）为单位给出，括号内的数值为95%最高后验密度（95%HPD）对应的置信下限与上限值。
***** = 模型未收敛。