Summary statistics from epigenome-wide association studies and meta-analysis comparing APOE ε4 and APOE ε2 allele carriers in Generation Scotland

These datasets contain full summary statistics for epigenome-wide association studies (EWASs) carried out using two methylation samples from the Generation Scotland: Scottish Family Health Study to investigate associations between blood-based DNA methylation and APOE ε4 vs. ε2 carrier status. The two samples were termed the "discovery" and "replication" samples and a meta-analysis of the EWAS results from the two samples was performed. These datasets are described fully in the associated preprint, which is available on bioRxiv (https://www.biorxiv.org/content/10.1101/815035v2.full).

本数据集包含使用采自苏格兰世代研究（Generation Scotland）：苏格兰家庭健康研究的两份甲基化样本开展的表观全基因组关联研究（epigenome-wide association studies, EWAS）的完整汇总统计量，旨在探究血液DNA甲基化与载脂蛋白E ε4（APOE ε4）、载脂蛋白E ε2（APOE ε2）携带者状态之间的关联。该两份样本分别被命名为"发现队列"与"验证队列"，并针对两份样本的EWAS结果开展了荟萃分析。本数据集的详细说明见于相关预印本，该预印本可在bioRxiv平台获取，链接为https://www.biorxiv.org/content/10.1101/815035v2.full。