Table_1_The burden of testicular cancer from 1990 to 2019 in the Middle East and North Africa region.docx

BackgroundThe incidence rate of testicular cancer has risen in many countries during recent decades. This study aimed to outline the impact of testicular cancer on the Middle East and North Africa (MENA) region from 1990 to 2019, examining its burden by age group and according to the socio-demographic index (SDI).
MethodsData on the incidence, death, and disability-adjusted life-years (DALYs) due to testicular cancer were retrieved from the Global Burden of Disease study 2019. The counts and age-standardized rates (per 100,000) were reported, and all rates were accompanied by 95% uncertainty intervals (UIs).
ResultsIn MENA, the age-standardized incidence rate of testicular cancer was 1.4 per 100,000 in 2019, showing a 244.0% increase since 1990. Similarly, the annual death rate, at 0.1, experienced a 2.6% rise during the same period. In 2019, testicular cancer accounted for 31.1 thousand DALYs, marking an age-standardized rate of 5.0, which was 2.8% higher than in 1990. The 1-4 age group exhibited the largest incidence rate in 2019. In addition, in both 1990 and 2019 the MENA/Global DALY ratio was higher than one in the 1-14 year age groups. During the period 1990 to 2019, the age-standardized DALY rate of testicular cancer steadily rose with higher SDI values, except for a decrease observed at an SDI of 0.8.
ConclusionOver the last thirty years, there has been a notable rise in the burden of testicular cancer in the MENA region.

背景：近数十年来，全球诸多国家的睾丸癌发病率呈持续上升态势。本研究旨在梳理1990年至2019年间睾丸癌对中东与北非（MENA）地区的影响，并按年龄组及社会人口指数（SDI）分析该疾病的疾病负担。
研究方法：本研究的数据提取自2019年全球疾病负担研究（Global Burden of Disease Study 2019），涵盖睾丸癌相关的发病、死亡及伤残调整寿命年（Disability-Adjusted Life Years, DALYs）数据；研究报告了发病数与年龄标准化率（每10万人），且所有率值均附带95%不确定区间（Uncertainty Intervals, UIs）。
研究结果：2019年，中东与北非（MENA）地区睾丸癌的年龄标准化发病率为每10万人1.4例，较1990年增长244.0%；同期年死亡率为0.1/10万，增幅达2.6%。2019年，睾丸癌相关伤残调整寿命年达31.1千，年龄标准化率为5.0，较1990年升高2.8%。2019年，1~4岁年龄组的睾丸癌发病率最高。此外，在1990年与2019年，1~14岁年龄组的中东与北非地区/全球伤残调整寿命年比值均大于1。1990年至2019年间，睾丸癌的年龄标准化伤残调整寿命年率随社会人口指数（SDI）升高呈稳步上升趋势，仅当SDI为0.8时出现下降。
结论：近三十年来，中东与北非（MENA）地区的睾丸癌疾病负担显著上升。