Layer-by-layer self-assembled emerging systems for nanosized drug delivery - supplementary dataset

New frontiers in the development of stimuli-responsive surfaces that offer switchable properties according to the end-use application have added a new dimension to the design of drug-delivery systems (DDS). In this respect, layer-by-layer (LbL) self-assembled technologies have attracted interest in nano-DDS (NDDS) design due to the advantage of encapsulating different drug types either individually or in multiple formulations as an easy-to-apply and cost-effective strategy. LbL-based microcapsules and core-shell structures in the form of polyelectrolyte multilayers (PEMs) have been proposed as versatile vehicles for NDDS over the last quarter. This review aims to provide a global view of LbL-PEMs used as templates in NDDS for the last 5 years with an emphasis on emerging drug loading and release strategies.可根据最终应用场景实现特性切换的刺激响应型表面（stimuli-responsive surfaces）开发新前沿，为给药系统（drug-delivery systems, DDS）的设计增添了全新维度。在此研究方向下，层层（layer-by-layer, LbL）自组装技术凭借实施简便、成本低廉的优势，可单独或复配包载多种不同类型的药物，因此在纳米给药系统（nano-DDS, NDDS）的设计中受到广泛关注。近25年来，以聚电解质多层膜（polyelectrolyte multilayers, PEMs）为形式的基于LbL的微胶囊与核壳结构，已被提出作为纳米给药系统的多功能载体。本综述旨在全面梳理近5年来以LbL-PEMs为模板的纳米给药系统研究，并重点关注新兴的药物负载与释放策略。