Additional file 1 of Integrated study of systemic and local airway transcriptomes in asthma reveals causal mediation of systemic effects by airway key drivers

Additional file 1: Table S1. Characteristics of the participants who provided nasal samples. Table S2. NK cell-mediated cytotoxicity PBMC module eQTLs. Table S3. Interleukin production PBMC module eQTLs. Table S4. Nasal TCA cycle module eQTLs. Table S5. PBMC asthma genes. Table S6. PBMC NK cell-mediated cytotoxicity module genes. Table S7. PBMC interleukin production module genes. Table S8. Key driver analysis results for the PBMC NK cell-mediated cytotoxicity module. Table S9. Key driver analysis results for the PBMC interleukin production module. Table S10. Nasal asthma genes. Table S11. Nasal Myeloid, Mast cell and Plasma cell fractions. Table S12. Key driver analysis results for the nasal TCA cycle module.

附加文件1：表S1 提供鼻腔样本的参与者特征。表S2 自然杀伤（natural killer, NK）细胞介导的细胞毒性外周血单个核细胞（peripheral blood mononuclear cell, PBMC）模块表达数量性状基因座（expression quantitative trait locus, eQTL）。表S3 外周血单个核细胞白细胞介素产生模块表达数量性状基因座。表S4 鼻腔三羧酸循环（tricarboxylic acid cycle, TCA cycle）模块表达数量性状基因座。表S5 外周血单个核细胞哮喘相关基因。表S6 外周血单个核细胞自然杀伤细胞介导的细胞毒性模块基因。表S7 外周血单个核细胞白细胞介素产生模块基因。表S8 外周血单个核细胞自然杀伤细胞介导的细胞毒性模块关键驱动基因分析结果。表S9 外周血单个核细胞白细胞介素产生模块关键驱动基因分析结果。表S10 鼻腔哮喘相关基因。表S11 鼻腔髓系细胞、肥大细胞及浆细胞组分占比。表S12 鼻腔三羧酸循环模块关键驱动基因分析结果。