Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese

We performed a multistage genome-wide association study on 2,949 pulmonary TB patients and 5,090 healthy controls (833 cases and 1,220 controls were genome-wide genotyped in discovery stage) from Han Chinese population. The summary data for the discovery stage from the published study is available in this site, as well as gwas.bio-x.cn and analysis.bio-x.cn/gwas, for download.<br><b><i>Data Download Agreement: </i><br><br>If you download these data, you and your immediate collaborators (“investigators”) acknowledge and agree to all of the following conditions: </b><br><br>&gt; These data are provided on an "AS-IS" basis, without warranty of any type, expressed or implied, including but not limited to any warranty as to their performance, merchantability, or fitness for any particular purpose;<br><br>&gt; Investigators will use these results for scientific research and educational use only;<br><br>&gt; Reposting or public distribution of these results files is prohibited;<br><br>&gt; Investigators certify that they are in compliance with all applicable local, state, and federal laws or regulations and institutional policies regarding human subjects and genetics research; <br><br>&gt; Investigators will cite the appropriate publication(s) in any communications or publications arising directly or indirectly from these data; <br><br>&gt; Investigators will never attempt to identify any participant. <br><br>&gt; Appropriate use of these data requires considerable attention to detail, prior experience, and technical skill. If investigators use these data, any and all consequences are entirely their responsibility.<br>

本研究针对汉族人群开展多阶段全基因组关联研究（genome-wide association study, GWAS），共纳入2949名肺结核（pulmonary TB）患者与5090名健康对照，其中发现阶段（discovery stage）完成了833例病例与1220例对照的全基因组基因分型。本研究已公开的发现阶段汇总数据可在本网站、gwas.bio-x.cn以及analysis.bio-x.cn/gwas获取下载。<br><b><i>数据下载协议：</i></b><br><br>若您下载本数据，您及直接合作者（以下统称"研究者"）须确认并同意以下全部条款：<br><br>&gt; 本数据按"现状"提供，不提供任何明示或默示的担保，包括但不限于关于其性能、适销性或特定用途适用性的任何担保；<br><br>&gt; 仅可将本数据用于科学研究与教育用途；<br><br>&gt; 禁止对本数据结果文件进行转发或公开分发；<br><br>&gt; 研究者须承诺，其已遵守所有适用于人类受试者与遗传学研究的当地、州级、联邦法律法规及机构政策；<br><br>&gt; 若基于本数据开展直接或间接相关的学术交流或发表成果，研究者须引用相关的已发表文献；<br><br>&gt; 研究者不得尝试识别任何研究受试者；<br><br>&gt; 合理使用本数据需要细致严谨的操作、过往相关经验与专业技术能力。若研究者使用本数据，由此产生的一切后果均由其自行承担。