Co-culture of Aspergillus nidulans and Aspergillus fumigatus

Fungal genomes contain genes for far more secondary metabolites (SMs) than have yet been identified in the laboratory. To explore silent SMs, co-culturing method has attracted much attention in this field. However, study of the molecular mechanisms underlying this effect is in its infancy. For this purpose, we used strains of Aspergillus nidlulans and Aspergillus fumigatus in co-culture to enhance SM production.

真菌基因组编码的次生代谢物（secondary metabolites，SMs）种类，远多于实验室迄今已鉴定出的该类代谢物总量。为探究沉默次生代谢物，共培养方法在该领域广受关注。然而，针对该共培养提升次生代谢物产量的效应背后的分子机制，相关研究尚处起步阶段。为此，本研究采用构巢曲霉（Aspergillus nidulans，原文笔误为nidlulans）与烟曲霉（Aspergillus fumigatus）的菌株进行共培养，以提升次生代谢物产量。