A cytomegalovirus encoded lncRNA blocks cell cycle progression. Fisher et al
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RNA2.7 is the most abundant viral transcript generated by the HCMV virus.
We uncover the RNA stability regulation mediated by RNA2.7 and characterize its effects over the cell cycle, which supports the infection of rapidly proliferating cells.
RNA2.7是人类巨细胞病毒(Human Cytomegalovirus, HCMV)所产生的丰度最高的病毒转录本。本研究揭示了由RNA2.7介导的RNA稳定性调控机制,并系统表征了其对细胞周期的调控效应,该效应可支持人类巨细胞病毒在快速增殖细胞中的感染过程。



