Sixty three miRNAs significantly altered following SNL surgery.

The set of 63 miRNAs found to be most differentially expressed in L4 ipsilateral DRGs of the SNL cohort compared to their contralateral counterpart. The set was derived based on the filters of t-test p-value<0.01 (FDR<2%) and fold change (at least two fold in either direction). The majority of these miRNAs were down-regulated in the ipsilateral relative to the contralateral DRGs, including the set of 10 miRNAs (bold type, top section of the table) whose expression level was almost undetectable in L4 ipsilateral DRGs (see text). The table was sorted by signed fold change (FC) for SNL L4. Bold type numbers indicate at least 2 fold up- or down-regulation in ipsilateral relative to contralateral DRGs. Number of mRNA transcripts containing predicted target sites for these 63-set miRNAs based on TargetScan predictions is shown. For increasing the stringency of the predicted target sites of the 63 miRNAs, we applied a context score filter above the 60th percentile.
**No prediction from TargetScan database.

本数据集包含63个在脊神经结扎（SNL）组大鼠L4同侧背根神经节（dorsal root ganglion, DRG）中，与对侧对应节段相比差异表达最显著的微小RNA（miRNAs）。该数据集的筛选标准为t检验p值<0.01（错误发现率FDR<2%），且倍数变化（fold change, FC）在任一方向上至少达到2倍差异。其中绝大多数微小RNA在同侧背根神经节中呈下调表达，包括表格上部以粗体标注的10个微小RNA——这类微小RNA在L4同侧背根神经节中的表达水平几乎无法检测（详见正文）。本表格依据脊神经结扎组L4节段的符号化倍数变化进行排序，表格中的粗体数字代表对应微小RNA在同侧与对侧背根神经节间的表达差异至少达到2倍（上调或下调）。表格同时列出了基于TargetScan数据库预测的、可与这63个微小RNA结合并含有预测靶点的信使RNA（mRNA）转录本数量。为提升靶点预测的严格性，我们设置了上下文评分位于第60百分位以上的筛选阈值。**无TargetScan数据库预测结果。