Longitudinal LFP recordings from female apoE3-KI and apoE4-KI mice at rest and subsequent spatial memory performance

This data set consists of recordings collected in the lab of Yadong Huang at UCSF and the Gladstone Institutes. The experiment consisted of two cohorts of female apoE3-KI and apoE4-KI mice: one screen cohort which had electrophysiological recordings at 12–18 months and Morris Water Maze (MWM) at 13–19 months and one replication cohort which had electrophysiological recordings at 5–8 months, 9–11 months, and 13–17 months, MWM at 5-8 months, open field, elevated plus maze, and MWM at 14–18 months, and Active Place Avoidance (APA) and hot plate at 15–20 months. A Neuronexus A4x8-400-200-704-CM32 silicon electrode probe was chronically implanted in the right dorsal hippocampus with 32 sites spanning all cellular and subcellular layers of CA1, CA3, and DG. Recordings were taken using a Spike Gadgets system while the animal was freely moving in its home cage (mostly sleep and awake rest) over 5 60 minute sessions unrelated to task performance. Included data are preprocessed to reduce file size. Data include 0-300Hz LFP filtered data downsampled to 1kHz, behavioral results, mouse position tracking, and metadata for each mouse, probe, and recording epoch. Analysis code is deposited at https://github.com/emilyasterjones/SWR-predictions. Results from this experiment are described in: Jones, E. A., Gillespie, A. K., Yoon, S. Y., Frank, L. M. & Huang, Y. Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer’s Disease Mouse Model. bioRxiv 596569 (2019). doi:10.1101/596569

本数据集由加州大学旧金山分校（University of California, San Francisco, UCSF）黄亚东（Yadong Huang）实验室与格拉德斯通研究所（Gladstone Institutes）采集的实验记录数据组成。本实验包含两个队列的雌性载脂蛋白E3敲入（apoE3-KI）与载脂蛋白E4敲入（apoE4-KI）小鼠：其一为筛选队列，在12~18月龄时开展电生理记录，在13~19月龄时开展莫里斯水迷宫（Morris Water Maze, MWM）实验；其二为重复队列，分别在5~8月龄、9~11月龄及13~17月龄时进行电生理记录，在5~8月龄时开展莫里斯水迷宫实验，在14~18月龄时开展旷场实验、高架十字迷宫实验及莫里斯水迷宫实验，并在15~20月龄时开展主动位置回避（Active Place Avoidance, APA）实验与热板实验。
研究人员使用Neuronexus A4x8-400-200-704-CM32硅基电极探针，对小鼠右侧背侧海马进行慢性植入，该探针拥有32个记录位点，覆盖CA1、CA3及齿状回（Dentate Gyrus, DG）的全部细胞层与亚细胞层。记录过程采用Spike Gadgets系统完成，实验期间小鼠可在饲养笼中自由活动（主要处于睡眠与清醒静息状态），共完成5次时长60分钟的记录时段，且所有记录均与任务操作无关。
本数据集收录的数据已进行预处理以缩减文件体积，具体包含经0~300Hz滤波、下采样至1kHz的局部场电位（Local Field Potential, LFP）数据、行为学实验结果、小鼠位置追踪数据，以及每只小鼠、每根探针与每个记录时段的元数据。
本实验的分析代码已上传至https://github.com/emilyasterjones/SWR-predictions。该实验的相关研究成果已发表于：Jones, E. A., Gillespie, A. K., Yoon, S. Y., Frank, L. M. & Huang, Y. Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer’s Disease Mouse Model. bioRxiv 596569 (2019). doi:10.1101/596569