Association rate, dissociation rate, and equilibrium dissociation constants of Trn1 and wild-type and mutant FUS-NLS.

The 12 ALS mutations are organized in the order of decreasing affinity.aThe relative affinity is defined as KD of WT (M) divided by KD of the FUS-NLS mutants (M).The correlation coefficient χ2 value is a statistical measure of how closely the fitted curve fits the experimental data [15] (see Methods).

12种肌萎缩侧索硬化（ALS，Amyotrophic Lateral Sclerosis）相关突变按照亲和力递减的顺序排列。相对亲和力定义为野生型（WT，Wild Type）的解离常数（KD，dissociation constant）与FUS-NLS突变体的解离常数（KD）的比值，二者单位均为摩尔（M）。卡方（χ²）值是衡量拟合曲线与实验数据契合程度的统计学指标[15]（详见方法部分）。