Aerobic Oxynitration of Alkynes with tBuONO and TEMPO

An efficient method for stereoselective nitroaminoxylation of alkyne has been reported. The reaction enjoys a broad substrate scope, good functional group tolerance, and high yields. Synthetically useful α-nitroketones can be accessed through these products in a single step.

本研究报道了一种可实现炔烃立体选择性硝基氨氧化反应的高效方法。该反应具备宽泛的底物适用范围、优异的官能团耐受性与较高的反应收率。通过该反应产物可一步制备具有合成应用价值的α-硝基酮类化合物。