Human Glioblastoma

Summary: Astrocytomas can be categorized as either low grade or high grade (glioblastoma). Low grade astrocytomas are not generally aggressive tumors whereas glioblastomas are and in turn have a high mortality rate. The purpose of this experiment is to identify genetic differences between the two types. Hypothesis: There will be a difference in RNA expression between high grade and low grade tumors. Specific Aim: To identify genes which make a tumor high grade or low grade Keywords: disease, cancer grade Comparison of 8 high grade and 12 low grade tumors摘要：星形细胞瘤（Astrocytomas）可分为低级别与高级别两类，其中高级别星形细胞瘤即胶质母细胞瘤（glioblastoma）。低级别星形细胞瘤通常不具有侵袭性，而胶质母细胞瘤侵袭性强且死亡率较高。本实验旨在探究这两类肿瘤之间的遗传学差异。 研究假设：高级别与低级别肿瘤的RNA表达存在差异。 具体研究目标：鉴定出可区分肿瘤为高级别或低级别的相关基因。 关键词：疾病，癌症分级 本研究纳入8例高级别肿瘤与12例低级别肿瘤进行对照分析。