Transcriptome profiling for hidradenitis suppurativa

Hidradenitis Suppurativa (HS) is a debilitating chronic inflammatory disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum. Through the use of transcriptomic approaches, we characterize the inflammatory responses in HS in depth, revealing the cell types and immune responses involved. We conducted RNA-seq on whole blood and skin obtained from HS patients, and comparing them against control individuals

化脓性汗腺炎（Hidradenitis Suppurativa, HS）是一种衰弱性慢性炎症性疾病，以慢性脓肿形成、腹股沟、腋窝及会阴多发引流窦道形成为特征。本研究通过转录组学方法，对化脓性汗腺炎的炎症反应进行了深度表征，揭示了其所涉及的细胞类型与免疫应答机制。我们采集了化脓性汗腺炎患者的全血与皮肤样本，并将其与健康对照个体的样本进行比对，开展了RNA测序（RNA-seq）。