Supplementary Material for: Family history of stroke is associated with large- and small-vessel etiology: a systematic review and meta-analysis

Background:
Several studies have investigated the association between family history of stroke (FHS) and stroke etiology, recurrence or mortality, however the results have been discrepant. We conducted a systematic review with meta-analysis to further evaluate the associations.
Materials and Methods:
We searched Scopus database using the term “family history” AND “stroke” up to December 2023 to identify observational studies and systematic reviews reporting both the prevalence of FHS and the rates of stroke etiology or recurrence or mortality. Case reports, series and narrative reviews were excluded. We used odds ratio as a common measure of association and I2 to determine heterogeneity of effects across studies.
Results:
We have identified 22 articles (130 999 patients, 53% female), which met the pre-specified inclusion criteria. After pooling the results, FHS was associated with large-vessel (OR, 1.24, 95%CI [1.07-1.44]), as well as small-vessel (OR, 1.17, 95%CI [1.05-1.31]), but not cardioembolic stroke etiology (OR, 0.74, 95%CI [0.60-0.90]). There was no relationship between FHS and stroke recurrence (OR, 1.16, 96%CI [0.84-1.61]), nor mortality (0.94, 95%CI [0.63-1.41]).
Conclusions:
FHS is associated with large- and small-vessel stroke etiology, but not stroke recurrence or mortality. These findings might be useful to physicians caring for stroke patients in their everyday practice.

背景：
既往已有多项研究探讨脑卒中家族史（family history of stroke, FHS）与脑卒中病因、复发或病死率之间的关联，但所得结果并不一致。本研究通过系统评价结合Meta分析，进一步评估上述关联。
材料与方法：
本研究于2023年12月前在Scopus数据库中以"family history" AND "stroke"为检索式进行检索，旨在筛选同时报告脑卒中家族史患病率及脑卒中病因、复发或病死率的观察性研究与系统评价。本研究排除病例报告、病例系列及叙述性综述。本研究采用比值比（odds ratio, OR）作为关联的常用衡量指标，并通过I²值评估各研究间的效应异质性。
结果：
本研究共纳入符合预设纳入标准的22篇文献，涉及130999名患者，其中女性占比53%。合并分析结果显示，脑卒中家族史与大血管性脑卒中（OR=1.24，95%CI[1.07-1.44]）及小血管性脑卒中（OR=1.17，95%CI[1.05-1.31]）均存在关联，但与心源性栓塞性脑卒中病因无显著关联（OR=0.74，95%CI[0.60-0.90]）。此外，脑卒中家族史与脑卒中复发（OR=1.16，96%CI[0.84-1.61]）及病死率（OR=0.94，95%CI[0.63-1.41]）均无显著关联。
结论：
综上，脑卒中家族史与大、小血管性脑卒中病因相关，但与脑卒中复发及病死率无关联。本研究结果可为临床医师日常诊疗脑卒中患者提供参考依据。