Polygamy, sexual behavior in a population under risk for prostate cancer diagnostic: an observational study from the Black Sea Region in Turkey

ABSTRACT Aim: Although prostate cancer (PCa) is the most common cancer type in men, a replaceable risk factor has not yet been established. In our study, we assessed the relationship between the number of sexual partners, age of first sexual experience and age of first masturbation and prostate cancer incidence. Materials and Methods: In Ordu University Department of Urology between January 2013 and September 2016, in PSA elevation and rectal examination, patients with prostate biopsy were evaluated due to nodule palpation in the prostate. At younger ages and at present, their first masturbation ages, first sexual debut ages, and total sexual partner numbers were recorded. The correlation between the obtained data and PCa frequency was evaluated. Results: The study included 146 patients with PCa identified on biopsy and 171 patients with benign biopsy results who answered the questions. 66.7% of the ones whose biopsy results were benign and 40.6% of cancer suspects had only one sexual partner. The median number of sexual partners was 1±4 (1-100) in the benign group and 2±6 (1-500) in the malignant group (p=0.039). There was a negative correlation between age of first sexual debut and number of partners (r: −0,479; p <0.001). Conclusion: In our study, it appears that there may be an association between the number of sexual partners and prostate cancer in the patient group with PSA level above 4ng/mL. Avoidance of sexual promiscuity or participation in protected sex may be beneficial to protect against prostate cancer.

摘要：
目的：尽管前列腺癌（Prostate Cancer，PCa）是男性最常见的恶性肿瘤，目前尚未确立明确的可干预危险因素。本研究旨在探讨性伴侣数量、首次性行为年龄及首次自慰年龄与前列腺癌发病率之间的关联。
材料与方法：2013年1月至2016年9月，于奥尔杜大学泌尿外科，对因血清前列腺特异性抗原（Prostate Specific Antigen，PSA）升高、直肠指检触及前列腺结节而接受前列腺活检的患者开展研究。收集患者早年及当前的首次自慰年龄、首次性行为年龄与总性伴侣数量，分析上述数据与前列腺癌患病频率的相关性。
结果：本研究共纳入146例活检确诊为前列腺癌的患者，以及171例活检结果为良性且完成问卷的患者。良性活检组中66.7%的患者仅拥有1个性伴侣，而前列腺癌患者组中仅40.6%的患者仅拥有1个性伴侣。良性组的性伴侣数量中位数为1±4（范围1~100），恶性组为2±6（范围1~500），组间差异具有统计学意义（p=0.039）。首次性行为年龄与性伴侣数量呈负相关（相关系数r=-0.479，p<0.001）。
结论：本研究结果显示，在血清PSA水平高于4ng/mL的患者群体中，性伴侣数量与前列腺癌可能存在关联。避免性滥交或采取保护性性行为，或有助于预防前列腺癌。