SARS-CoV-2 Infection and Placental Pathology Infecção por SARS-CoV-2 e patologia placentária

Abstract Placental pathophysiology in SARS-CoV-2 infection can help researchers understand more about the infection and its impact on thematernal/neonatal outcomes. This brief review provides an overview about some aspects of the placental pathology in SARSCoV- 2 infection. In total, 11 papers were included. The current literature suggests that there are no specific histopathological characteristics in the placenta related to SARSCoV- 2 infection, but placentas frominfected women aremore likely to show findings of maternal and/or fetal malperfusion. The most common findings in placentas from infected women were fibrin deposition and intense recruitment of inflammatory infiltrates. The transplacental transmission of this virus is unlikely to occur, probably due to low expression of the receptor for SARS-CoV-2 in placental cell types. Further studies are needed to improve our knowledge about the interaction between the virus and the mother-fetus dyad and the impact on maternal and neonatal/fetal outcomes.

摘要 严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）感染相关的胎盘病理生理学研究，可帮助研究人员深入了解该感染及其对孕产妇与新生儿结局的影响。本简要综述概述了SARS-CoV-2感染相关胎盘病理的若干方面，共纳入11篇文献。现有文献表明，目前尚未发现与SARS-CoV-2感染相关的胎盘特异性组织病理学特征，但感染孕妇的胎盘更易出现母体和/或胎儿灌注不良的表现。感染孕妇的胎盘最常见的病理改变为纤维蛋白沉积及大量炎性细胞浸润。该病毒经胎盘传播的可能性极低，这可能是由于胎盘细胞中SARS-CoV-2受体的表达水平较低。仍需开展进一步研究，以加深我们对该病毒与母胎交互作用及其对孕产妇和新生儿/胎儿结局影响的认知。