Crystal structure of p38alpha in complex with a reduced photoswitchable 2-Azothiazol-based Inhibitor (compound 31)

Crystal structure of p38alpha in complex with a reduced photoswitchable 2-Azothiazol-based Inhibitor (compound 31) Descriptor: 3-(2,5-dimethoxyphenyl)-~{N}-[4-[4-(4-fluorophenyl)-2-(2-phenylhydrazinyl)-1,3-thiazol-5-yl]pyridin-2-yl]propanamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside Authors: Mueller, M.P, Rauh, D. Deposit date: 2018-10-15 Release date: 2019-04-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: 2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach. Photochem. Photobiol. Sci., 18, 2019

与还原型光开关2-噻唑偶氮类抑制剂（化合物31）结合的p38α晶体结构。其结构表征物包括：3-(2,5-二甲氧基苯基)-~N-[4-[4-(4-氟苯基)-2-(2-苯基肼基)-1,3-噻唑-5-基]吡啶-2-基]丙酰胺、丝裂原活化蛋白激酶14（Mitogen-activated protein kinase 14）以及辛基β-D-吡喃葡萄糖苷（octyl beta-D-glucopyranoside）。作者为Mueller, M.P.与Rauh, D.。沉积日期：2018-10-15；发布日期：2019-04-17；最后修改日期：2024-01-24。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.7 Å）。引用文献：《2-偶氮类、2-二氮杂环庚烯-噻唑类与2-偶氮咪唑类光开关激酶抑制剂：光开关抑制剂研究方法的局限与陷阱》，刊载于《光化学与光生物学科学》（Photochem. Photobiol. Sci.），第18卷，2019年。