Palladium-Catalyzed C−H Aminations of Anilides with <i>N</i>-Fluorobenzenesulfonimide

The first amide-directed, palladium-catalyzed, intermolecular, highly selective C−H aminations with the non-nitrene-based nitrogen source N-fluorobenzenesulfonimide have been developed. This methodology might provide a new pathway for directed metal-catalyzed aromatic C−H amination.本研究首次开发了以非氮宾类氮源N-氟代苯磺酰亚胺（N-fluorobenzenesulfonimide）为底物的酰胺导向、钯催化的分子间高选择性C−H胺化反应。该方法可为定向金属催化的芳香族C−H胺化反应提供全新的合成路径。