Human Wharton's jelly-derived mesenchymal stem cells alleviate Concanavalin A-induced fulminant hepatitis by repressing NF-κB signaling and glycolysis

RNA sequencing of mouse liver tissues 24 hours after Concanavalin A (Con A) administration. Mouse liver tissues from Control (Ctrl), Con A, and Con A plus human Wharton's jelly-derived mesenchymal stem cells (Con A + MSCs) (4 replicates for each group) were collected and sequenced to identify the differently expressed genes and related pathways. Con A was administrated at 15mg/kg body weight and MSCs were infused 30 mins after Con A administration.

本数据集对应伴刀豆球蛋白A（Concanavalin A，Con A）给药后24小时的小鼠肝组织RNA测序。研究收集了对照组（Control组，简称Ctrl）、Con A组以及Con A联合人沃顿胶源性间充质干细胞（human Wharton's jelly-derived mesenchymal stem cells，MSCs）的小鼠肝组织，每组设置4个生物学重复，通过测序鉴定差异表达基因并解析其相关调控通路。实验中Con A以15mg/kg体重的剂量给药，MSCs于Con A给药后30分钟完成输注。