Clinical manifestations in anti-Ro52/SS-a antibody-seropositive patients with Sjögren's syndrome

<b>Background:</b> The relationship between anti-Ro52/SS-A antibody (anti-Ro52) and the clinical manifestations of Sjögren's syndrome (SS) has not been fully clarified. We determined the clinical factors relevant to SS patients with anti-Ro52. <b>Methods:</b> We conducted a retrospective study of 149 subjects suspicious for SS and 50 healthy control subjects. We analyzed items of the American-European Consensus Group (AECG) criteria and the EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI). <b>Results:</b> SS was documented in 115 subjects. Anti-Ro52 was observed in 70 SS patients. Anti-Ro52 positivity showed a significantly higher association with anti-Ro60 positivity than with anti-centromere antibody (ACA) positivity (<i>p</i> &lt; 0.05). Regarding the difference in the anti-Ro52 concentration, we observed six significantly relevant components: two AECG components and four non-AECG components. The anti-Ro52 concentration well-discriminated three clinical factors (ROC AUC &gt;0.75), i.e., ACA seropositivity, ESSDAI score ≥1, and RF, and it moderately discriminated high serum IgG, focus score ≥1, and anti-La/SS-B antibody seropositivity (ROC AUC &gt;0.7). A linear relationship between the ESSDAI score and the anti-Ro52 concentration was observed. <b>Conclusion:</b> A significant association between clinical factors (including the ESSDAI) and the anti-Ro52 concentration were revealed. Anti-Ro52 was more highly associated with anti-Ro60 positivity than with ACA positivity.

<b>背景：</b>抗Ro52/SS-A抗体（anti-Ro52）与干燥综合征（Sjögren's syndrome, SS）的临床表现之间的关联尚未完全阐明。本研究旨在明确抗Ro52阳性SS患者的相关临床因素。<b>方法：</b>本研究纳入149例疑似SS患者及50例健康对照者，开展回顾性分析。对美欧共识小组（American-European Consensus Group, AECG）标准条目及欧洲抗风湿病联盟干燥综合征疾病活动指数（EULAR Sjögren's Syndrome Disease Activity Index, ESSDAI）进行分析。<b>结果：</b>最终确诊SS的受试者共115例，其中70例为抗Ro52阳性患者。抗Ro52阳性与抗Ro60（anti-Ro60）阳性的相关性显著高于其与抗着丝粒抗体（anti-centromere antibody, ACA）阳性的相关性（<em>p</em> < 0.05）。针对抗Ro52浓度的差异分析显示，共存在6个具有显著相关性的指标：2项AECG标准相关组分及4项非AECG标准相关组分。抗Ro52浓度可良好区分3项临床因素（受试者工作特征曲线下面积ROC AUC > 0.75），即ACA血清阳性、ESSDAI评分≥1分及类风湿因子（RF）阳性；同时可中等程度区分高血清IgG水平、聚焦评分（focus score）≥1分及抗La/SS-B抗体（anti-La/SS-B antibody）血清阳性（ROC AUC > 0.7）。本研究观察到ESSDAI评分与抗Ro52浓度呈线性相关。<b>结论：</b>本研究揭示了包括ESSDAI在内的多项临床因素与抗Ro52浓度之间存在显著关联。抗Ro52阳性与抗Ro60阳性的相关性显著高于其与ACA阳性的相关性。