Observational Study on Treatment of Metastatic Colorectal Cancer and the Role of K-Ras

The purpose of this study is to describe the treatments received and outcomes of patients with metastatic colorectal cancer, what percentage of these patients have K-Ras mutation of the tumor, and to describe the costs of treatments. Information will also be collected regarding risk factors, variables among treatment centers and patients, and explorative analyses will be done to try to identify factors that impact prognosis and factors that predict tolerability and response to treatment.

本研究旨在描述转移性结直肠癌（metastatic colorectal cancer）患者接受的治疗方案与临床结局，统计该类患者中肿瘤携带K-Ras突变（K-Ras mutation）的比例，并分析相关治疗的成本开销。此外，本研究还将收集危险因素、治疗中心与患者层面的各类变量数据，并通过探索性分析尝试识别影响患者预后的因素，以及可预测治疗耐受性与治疗应答的相关因素。