RNAseq of bioprinted endothelial and microglia coculture models

This study investigates the use of 3D bioprinting technology to create endothelial cell and microglia cell coculture models for studying the effects of different glucose levels on diabetic conditions. The bioprinted models were subjected to varying glucose levels, and the responses of the cells were evaluated. The study aims to provide insights into the pathophysiology of diabetic conditions and to facilitate the development of new therapeutic interventions.

本研究探究了3D生物打印（3D bioprinting）技术构建内皮细胞（endothelial cell）与小胶质细胞（microglia cell）共培养模型（coculture models）的应用，该模型用于研究不同葡萄糖水平对糖尿病状态的影响。将该生物打印构建的模型置于不同葡萄糖浓度的培养环境中，并对细胞的响应进行了评估。本研究旨在为糖尿病状态的病理生理学机制提供新见解，并助力新型治疗干预手段的开发。