Prognostic significance of the angiopoietin-2 for early prediction of septic shock in severe sepsis patients: supplementary data

Aim: The current study investigated the plasma levels of angiopoietin-1/-2 and their association with clinical outcomes of sepsis. Methods: Angiopoietin-1 and -2 levels were quantified in plasma from 105 patients with severe sepsis by ELISA. Results: Angiopoietin-2 levels elevated according to the severity of sepsis progression. Angiopoietin-2 levels were correlatedwithmean arterial pressure and platelets counts, total bilirubin, creatinine, procalcitonin, lactate levels and SOFA score. Angiopoietin-2 levels accurately discriminated for sepsis with an AUC = 0.97 and septic shock from severe sepsis patients (AUC = 0.778). Conclusion: Plasma angiopoietin-2 levels may serve as an additional biomarker for severe sepsis and septic shock.

研究目的：本研究旨在探讨血管生成素-1/2（angiopoietin-1/-2）的血浆水平及其与脓毒症临床结局的关联。
研究方法：采用酶联免疫吸附试验（ELISA）对105例重症脓毒症患者的血浆样本中血管生成素-1与-2的水平进行定量检测。
研究结果：血管生成素-2的水平随脓毒症病情进展的严重程度升高。血管生成素-2的水平与平均动脉压、血小板计数、总胆红素、肌酐、降钙素原、乳酸水平及序贯器官衰竭评分（SOFA score）均存在相关性。血管生成素-2对脓毒症具有良好的鉴别诊断效能，曲线下面积（AUC）为0.97；同时可有效区分重症脓毒症与脓毒性休克患者，其曲线下面积为0.778。
研究结论：血浆血管生成素-2水平可作为重症脓毒症及脓毒性休克的辅助生物标志物。