Dissecting Expression Profiles of Gastric Precancerous Lesions and Early Gastric Cancer to Explore Crucial Molecules in Intestinal-type Gastric Cancer Tumorigenesis

To investigate the changes in molecular expression, biological processes, stemness, immune microenvironment, tumor hallmark activities and co-expression relationships during intestinal-type gastric cancer carcinogenesis and to excavate the prognostic information contained in the carcinogenesis process. RNA expression profiles of ninety-four gastroscope biopsy samples with different stages of precancerous lesions or early gastric cancers and their paired controls were detected by Agilent Microarray. RNA expression profiles of ninety-four gastroscope biopsy samples with different stages of precancerous lesions or early gastric cancers and their paired controls were detected by Agilent Microarray.

为探究肠型胃癌癌变过程中分子表达、生物学过程、干细胞性、免疫微环境、肿瘤特征活性及共表达关系的变化，并挖掘该癌变过程中蕴含的预后信息。本研究采用安捷伦微阵列（Agilent Microarray）检测了94例携带不同分期癌前病变或早期胃癌的胃镜活检样本及其配对对照样本的RNA表达谱。本研究采用安捷伦微阵列（Agilent Microarray）检测了94例携带不同分期癌前病变或早期胃癌的胃镜活检样本及其配对对照样本的RNA表达谱。