Metastases of breast cancer (U133A). Homo sapiens

Comparisons among breast cancer metastases at different organs revealed distinct microenvironments as characterized by cytokine content. Such microenvironment distinction might be important to dictate how the cancer cells adapt to survival before they successfully colonize. Keywords: Disease state analyses Overall design: 58 breast cancer metastases from different organs were profiled and compared by the expression level of over 400 cytokines. 36 samples were incuded in this series. 22 others as well as 7 of these 36 were profiled on U133plus2 platforms and included in series GSE14017.

对不同器官来源的乳腺癌转移灶开展比较分析后发现，其微环境存在显著差异，该差异以细胞因子（cytokine）的含量特征作为区分依据。此类微环境差异可能是决定癌细胞在成功定植前如何适应并存活的关键因素。
关键词：疾病状态分析
实验设计概况：本研究对58例不同器官来源的乳腺癌转移灶进行表达谱分析，并通过超过400种细胞因子的表达水平开展对比研究。本系列共纳入36份样本。另有22例样本以及该36份样本中的7例，均在U133plus2平台上完成表达谱检测，并被纳入数据集系列GSE14017。