Additional file 2 of Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atrophic gastritis

Supplementary Material 2: Additional file 2: Figure S2. Expression of classic markers in each T-cell subcluster and inferred TF activities of T-cell subclusters. (A) Bubble plot depicting the average expression levels and cellular fractions of selected stress-related heat shock marker genes in 3 defined T-cell subclusters. (B) Bubble plot depicting the average expression levels and percentages of exhaustion-related marker genes in 3 defined T-cell subclusters. (C) Bubble plot depicting the average expression levels and cellular fractions of effector function-related marker genes in 3 defined T-cell clusters. (D) Heatmap showing TF activity among different T-cell subclusters. (E) Heatmap showing TF activity among different T-cell subclusters in the CAG and control groups. CD4+ Tex: exhausted CD4+ T-cell subtype, CD8+ Tef: CD8+ T effector cell subtype, CD8+ Tsr: CD8+ T stress response.

补充材料2：附加文件2：图S2。各T细胞亚群的经典标志物表达情况及T细胞亚群的推定转录因子（Transcription Factor, TF）活性。（A）气泡图展示了3个明确划分的T细胞亚群中，筛选得到的应激相关热休克标志物基因的平均表达水平与细胞占比。（B）气泡图展示了3个明确划分的T细胞亚群中，耗竭相关标志物基因的平均表达水平与细胞占比。（C）气泡图展示了3个明确划分的T细胞簇中，效应功能相关标志物基因的平均表达水平与细胞占比。（D）热图展示了不同T细胞亚群间的转录因子活性。（E）热图展示了CAG组与对照组中不同T细胞亚群间的转录因子活性。CD4+ Tex：耗竭型CD4+ T细胞亚群，CD8+ Tef：CD8+ T效应细胞亚群，CD8+ Tsr：CD8+ T应激反应亚群。