SLC38A9 binds Ragulator:Rag dimers

The sodium-coupled neutral amino acid transporter 9 (SLC38A9 aka URLC11) is a lysosomal membrane protein mediating the transport of amino acids. It is proposed SLC38A9 acts as an amino acid sensor of the Ragulator and Rag GTPases complexes which are involved in the activation of mTORC1. The serine/threonine kinase mTORC1 regulates cellular homeostasis in response to many stimuli, such as nutrient status (for example via the transport of amino acids by SLC38A9) and energy level. SLC38A9 has been established to be an integral part of the Ragulator:Rag GTPase complex (Rebsamen et al. 2015, Wang et al. 2015, Jung et al. 2015).

钠偶联中性氨基酸转运蛋白9（SLC38A9，又称URLC11）是一种溶酶体膜蛋白，负责氨基酸的转运。有研究提出，SLC38A9充当Ragulator和Rag GTPases复合物的氨基酸传感器，这些复合物参与mTORC1的激活。丝氨酸/苏氨酸激酶mTORC1在多种刺激下调节细胞稳态，例如营养状况（例如通过SLC38A9转运氨基酸）和能量水平。SLC38A9已被确认为Ragulator:Rag GTPase复合体（Rebsamen等，2015年，Wang等，2015年，Jung等，2015年）的不可或缺组成部分。