<b>NECKCHECK PROJECT. Enhancing diagnostic accuracy in oropharyngeal squamous cell carcinoma through computer-based radiological tools</b>

Physicians frequently interpret radiological imaging tests for head and neck tumors in routine practice, without applying any protocol or systematized models for reading the images. This paper describes a newly developed guidance tool designed to enhance the visualization of radiological images of head and neck cancers, with a specific focus on the oropharyngeal region. The aim is to standardize image interpretation and reduce avoidable diagnostic errors among otolaryngologists. The primary objective of this research is to assess whether the implementation of a radiological checklist—developed through a comprehensive review of the scientific literature and integrated into a novel computerized interface—improves diagnostic accuracy in the evaluation squamous cell carcinoma of the oropharyngeal (OPSCC) by otolaryngologists (ENT).<b>Material and methods</b>. A comprehensive literature review was conducted, leading to the development of a radiological reading protocol that was subsequently digitized. A concordance study was designed in which a group of ENTs was presented with a randomized series of head and neck tumor images in two phases: before and after utilizing the tool. The results were compared with reports from specialist radiologists in the field. Diagnostic concordance was assessed using Cohen's Kappa coefficient. Additionally, descriptive and comparative analyses were performed, employing meta-analysis statistical tests and a mixed-effects linear model with a random effect component临床实践中，医师常需解读头颈部肿瘤的放射影像学检查结果，但并未遵循标准化方案或系统化模型开展影像阅片。本研究介绍一款全新研发的辅助阅片工具，旨在提升头颈部癌放射影像的可视化效果，且重点聚焦于口咽区域。该工具的研发目标为实现影像解读的标准化，减少耳鼻咽喉科医师可避免的诊断失误。本研究的主要目的为评估：经全面文献综述开发并集成至新型计算机化界面的放射学核查表，是否能够提升耳鼻咽喉科医师（Otolaryngologist，ENT）对口咽鳞状细胞癌（Oropharyngeal Squamous Cell Carcinoma，OPSCC）的诊断准确率。 **材料与方法** 本研究首先开展全面文献综述，据此制定放射学阅片方案并完成数字化转化。随后设计一致性研究：招募耳鼻咽喉科医师，分使用工具前、使用工具后两个阶段，为其呈现随机选取的头颈部肿瘤影像序列；将所得结果与该领域专科放射医师的报告进行比对。采用科恩kappa系数评估诊断一致性；此外，还通过荟萃分析统计检验与带随机效应分量的混合效应线性模型，开展描述性与比较性分析。