Crystal structure of MAT2a bound to allosteric inhibitor and in vivo tool compound 28
收藏Protein Data Bank Japan2024-05-01 更新2026-03-21 收录
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Crystal structure of MAT2a bound to allosteric inhibitor and in vivo tool compound 28 Descriptor: 7-chloranyl-4-(dimethylamino)-1-phenyl-quinazolin-2-one, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthase isoform type-2 Authors: Schimpl, M, De Fusco, C, Borjesson, U, Cheung, T, Collie, I, Evans, L, Narasimhan, P, Stubbs, C, Vazquez-Chantada, M, Wagner, D.J, Grondine, M, Tentarelli, S, Underwood, E, Argyrou, A, Bagal, S, Chiarparin, E, Robb, G, Scott, J.S. Deposit date: 2021-01-11 Release date: 2021-04-21 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.16 Å) Cite: Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model. J.Med.Chem., 64, 2021
结合变构抑制剂与体内工具化合物28的MAT2a晶体结构
描述物：7-氯-4-(二甲氨基)-1-苯基喹唑啉-2-酮、S-腺苷甲硫氨酸（S-adenosylmethionine）、S-腺苷甲硫氨酸合酶2型亚型
作者：Schimpl, M、De Fusco, C、Borjesson, U、Cheung, T、Collie, I、Evans, L、Narasimhan, P、Stubbs, C、Vazquez-Chantada, M、Wagner, D.J、Grondine, M、Tentarelli, S、Underwood, E、Argyrou, A、Bagal, S、Chiarparin, E、Robb, G、Scott, J.S.
提交日期：2021-01-11
发布日期：2021-04-21
最后修改日期：2024-05-01
测试方法：X射线衍射（1.16 Å）
引用文献：《基于片段设计强效MAT2a抑制剂并在MTAP缺失异种移植模型中开展体内评价》，《药物化学杂志》（J. Med. Chem.），64卷，2021年
创建时间：
2021-01-11
