Silver-Catalyzed Enantioselective Desymmetrization: Facile Access to Spirolactone-Pyrrolidines Containing a Spiro Quaternary Stereogenic Center

An unprecedented Ag(I)-catalyzed asymmetric desymmetrization of spiro cyclohexadienone lactones has been developed successfully, which performs well over a broad scope of substrates and provides a facile access to optically active spirolactone-pyrrolidines in high yields with excellent levels of diastereo-/enantioselectivities.

本研究成功开发了一种前所未有的一价银（Ag(I)）催化的螺环己二烯酮内酯（spiro cyclohexadienone lactones）不对称去对称化反应。该反应具备宽泛的底物适用范围，能够以高收率及优异的非对映选择性与对映选择性（diastereo-/enantioselectivities），便捷获得光学活性的螺内酯-吡咯烷（spirolactone-pyrrolidines）类化合物。