Effects of Gypenosides on intestinal microflora in mice

After administration of Gypenosides for 8 weeks, the level of TMAO in plasma of mice decreased significantly, because the first step of TMAO production was the decomposition of compounds containing trimethylamine structure in the intestine to produce trimethylamine. Therefore, we investigated the effect of Gypenosides on intestinal microflora, so as to determine its target

给予绞股蓝皂苷干预8周后，小鼠血浆中的三甲胺N-氧化物（trimethylamine N-oxide，简称TMAO）水平显著降低。这是因为TMAO生成的第一步，是肠道内含有三甲胺结构的化合物被分解为三甲胺。因此，本研究探究了绞股蓝皂苷对肠道菌群的影响，以明确其作用靶点。