Figure 8: Disease scores of mice infected with <i>P. aeruginosa</i> Xen41 following peptoid or antibiotic treatment

BALB/c mice were infected with <i>P. aeruginosa</i> via the intratracheal route and treated with TM1, TM5, TM6, or ciprofloxacin. A modified Karnofsky score was used to score any adverse effects observed over the course of the infection. (A) Average overall Karnofsky scores for each group of mice tested from 0 hours to 72 hours, with variance represented as SD. (B) Average Karnofsky scores for each group of mice over time, split into various categories tested. Columns marked with an ‘X’ indicate where a mouse was sacrificed ahead of schedule.将BALB/c小鼠经气管内途径感染铜绿假单胞菌（P. aeruginosa），随后分别予以TM1、TM5、TM6或环丙沙星处理。采用改良卡诺夫斯基评分（modified Karnofsky score）对感染过程中观察到的各类不良反应进行评分。(A) 各受试小鼠组在0小时至72小时内的平均总体卡诺夫斯基评分，变异程度以标准差（SD）表示。(B) 按所检测的不同类别分组后，各受试小鼠组随时间变化的平均卡诺夫斯基评分。标有"X"的列代表该组存在小鼠提前实施安乐死的情况。