Combination Chemotherapy With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. SU5416 may stop the growth of tumor cells by stopping blood flow to the tumor. It is not yet known whether combination chemotherapy will be more effective with or without SU5416 in treating metastatic colorectal cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy with or without SU5416 in treating patients who have metastatic colorectal cancer.

研究依据：化疗药物通过不同机制阻断肿瘤细胞分裂，使其增殖停滞或死亡。SU5416可通过阻断肿瘤血供抑制肿瘤细胞生长。目前尚不明确在转移性结直肠癌的治疗中，联合化疗联用SU5416是否较单纯联合化疗更具疗效。
试验目的：开展随机Ⅲ期临床试验，对比联用与不联用SU5416的联合化疗方案治疗转移性结直肠癌患者的疗效。