Expression data for Nonalcoholic fatty liver disease patients

Nonalcoholic fatty liver disease represents a spectrum of pathology that ranges from benign steatosis to potentially-progressive steatohepatitis and affects more than 30% of US adults. Advanced NAFLD is associated with increased morbidity and mortality from cirrhosis, primary liver cancer, cardiovascular disease and extrahepatic cancers. Accurate identification of patients at risk for advanced NAFLD is challenging. The aims of this study were to define the liver gene expression patterns that distinguish mild from advanced NAFLD and to develop a gene expression profile associated with advanced NAFLD. We analyzed total RNA from 72 patients with NAFLD (40 with mild NAFLD, fibrosis stage 0-1 and 32 with advanced NAFLD, fibrosis stage 3-4) and developed a gene profile associated with advanced NAFLD.

非酒精性脂肪性肝病（Nonalcoholic fatty liver disease, NAFLD）是一类病理谱覆盖良性脂肪变至具有潜在进展风险的脂肪性肝炎的疾病，在美国成年人群中的患病率超过30%。晚期非酒精性脂肪性肝病与肝硬化、原发性肝癌、心血管疾病及肝外恶性肿瘤所致的发病率与死亡率升高密切相关。精准识别晚期非酒精性脂肪性肝病高危患者仍颇具挑战。本研究旨在明确可区分轻度与晚期非酒精性脂肪性肝病的肝脏基因表达模式，并构建与晚期非酒精性脂肪性肝病相关的基因表达谱。本研究对72例非酒精性脂肪性肝病患者的总RNA进行了分析，其中40例为轻度非酒精性脂肪性肝病患者（纤维化分期0~1期），32例为晚期非酒精性脂肪性肝病患者（纤维化分期3~4期），并成功构建了与晚期非酒精性脂肪性肝病相关的基因表达谱。