Whole mouse genome expression analysis of host responses in Citrobacter rodentium infection. Mus musculus

Profiling of a total of 34,790 genes revealed a wide range of expression changes during the course of C. rodentium infection in murine colon. The majority of changes were observed during weeks 1 and 2, while relatively fewer changes were seen at week 3. Interestingly, chemokines made up 20% of the top twenty upregulated genes. Overall design: Mouse colon from pooled control or C. rodentium-infected mice.对共计34790个基因的表达谱分析，揭示了鼠柠檬酸杆菌（C. rodentium）感染小鼠结肠过程中广泛存在的基因表达变化。绝大多数表达变化发生于感染后第1周与第2周，第3周时观测到的变化相对较少。值得关注的是，在排名前20的上调基因中，趋化因子占比达20%。实验设计概述：样本取自合并对照组或经鼠柠檬酸杆菌感染的小鼠结肠组织。