Autophagy Targeting by Astaxanthin in PCOS

Dataset Description

This dataset was generated from a pilot, randomized, triple-blind, placebo-controlled clinical trial conducted at Omid Fertility Center (Tehran, Iran) between November 2023 and September 2024. The study investigated the effects of astaxanthin (AST) supplementation on clinical and molecular outcomes in women with polycystic ovary syndrome (PCOS) undergoing assisted reproductive technology (ART).

Research hypothesis: We hypothesized that AST supplementation would improve oocyte maturity and embryo quality in women with PCOS, potentially through modulation of the AMPK–autophagy–apoptosis signaling pathway in granulosa cells.

What the data shows: The dataset includes de-identified participant-level data on baseline characteristics (e.g., age, BMI, infertility history), controlled ovarian stimulation (COS) parameters, oocyte and embryo outcomes, and pregnancy outcomes. Data were collected prospectively during the trial and recorded in structured case report forms before being entered into Excel for analysis.

How the data can be interpreted and used: The dataset provides insights into the potential role of AST as an adjuvant in ART protocols for PCOS. Researchers may use these data to:

Reproduce or validate the reported analyses.
Conduct secondary analyses.
Integrate findings into systematic reviews or meta-analyses.

All data are fully de-identified. A data dictionary is provided to explain variable names and coding.

数据集说明
本数据集来源于2023年11月至2024年9月间，在伊朗德黑兰奥米德生育中心（Omid Fertility Center）开展的一项先导性、随机化、三盲、安慰剂对照临床试验。本研究针对接受辅助生殖技术（assisted reproductive technology, ART）的多囊卵巢综合征（polycystic ovary syndrome, PCOS）女性群体，探究了补充虾青素（astaxanthin, AST）对其临床与分子结局的影响。

研究假说：本研究提出假说，补充虾青素可改善多囊卵巢综合征女性的卵母细胞成熟度与胚胎质量，其潜在作用机制可能通过调控颗粒细胞内的腺苷酸活化蛋白激酶（AMPK）-自噬-凋亡信号通路实现。

数据内容：本数据集包含去标识化的受试者个体水平数据，涵盖基线特征（如年龄、体质量指数、不孕史）、控制性卵巢刺激（controlled ovarian stimulation, COS）参数、卵母细胞与胚胎结局以及妊娠结局。数据于试验期间前瞻性收集，先录入结构化病例报告表，随后导入Excel软件进行分析。

数据解读与应用方向：本数据集可为虾青素作为多囊卵巢综合征辅助生殖方案佐剂的潜在作用提供研究见解。研究人员可利用本数据集开展以下工作：
复刻或验证已报道的分析结果；
开展二次分析；
将研究发现整合至系统综述或荟萃分析中。

所有数据均已完成完全去标识化处理，同时附带数据字典以说明变量名称与编码规则。