effect of miR377 on doxorubicin induced cardiotoxicity

Doxorubicin is a widely used chemotherapy agent against various forms of cancer; however, it is also known to induce dose-dependent cardiotoxicity leading to adverse complications. Investigating the underlying molecular mechanisms and strategies to limit DOX-induced cardiotoxicity might have potential clinical implications. Our previous study has shown that expression of microRNA-377 (miR-377) increases in cardiomyocytes(CMs) after cardiac ischemia-reperfusion injury in mice; but its specific role in DOX-induced cardiotoxicity has not been elucidated. In the present study, we investigated the effect of anti-miR-377 on DOX-induced cardiac cell death, remodeling, and dysfunction.

多柔比星（Doxorubicin，DOX）是广泛用于多种癌症治疗的化疗药物，但该药物可引发剂量依赖性心脏毒性，进而导致不良并发症。探究多柔比星诱导心脏毒性的潜在分子机制及干预策略，具有潜在临床应用价值。本团队前期研究显示，小鼠心脏缺血再灌注损伤后，心肌细胞（CMs）内微小RNA-377（miR-377）的表达水平升高；但其在多柔比星诱导心脏毒性中的具体作用尚未阐明。本研究探讨了抗miR-377对多柔比星诱导的心肌细胞死亡、心肌重构及心功能障碍的影响。