The Ashkenazi-centric G334R variant of p53 is severely impaired for transactivation but retains tumor suppressor function in a mouse model

The data from "The Ashkenazi-centric G334R variant of p53 is severely impaired for transactivation but retains tumor suppressor function in a mouse model" is represented here in its entirety. This includes all uncut scanned films of Western blots (including BMH crosslinking and Co-IP). This includes all microscopy images taken for Proximity Ligation Assay. This includes excel and prism files that were used to quantify and analyze Western Blots (densitometry), Proximity Ligation Assay microscopy images, RT-qPCR, CHip-qPCR, the mouse Cancer Incidence Curve, and all mouse logs. The raw and processed data for the RNA sequencing can be found with the following GEO accession number: GSE277585. The raw and processed data for the CHiP sequencing can be found with the following GEO accession number: GSE277586.

本数据集完整收录了来自论文《以阿什肯纳兹人群为研究对象的p53 G334R变体：反式激活功能严重受损但在小鼠模型中仍保留抑癌功能》的全部数据。本数据集包含以下内容：所有未经剪辑的蛋白质免疫印迹（Western Blot）扫描胶片（包括BMH交联实验与免疫共沉淀（Co-IP）相关胶片）；所有用于邻近连接实验（Proximity Ligation Assay, PLA）的显微成像图片；用于定量分析蛋白质免疫印迹（光密度分析法）、邻近连接实验显微成像图片、实时定量逆转录聚合酶链反应（RT-qPCR）、染色质免疫共沉淀定量PCR（ChIP-qPCR）、小鼠肿瘤发生曲线以及所有小鼠饲养日志的Excel文件与Prism分析文件。RNA测序的原始与处理后数据可通过以下基因表达综合数据库（Gene Expression Omnibus, GEO）收录号GSE277585获取。染色质免疫共沉淀测序的原始与处理后数据可通过以下GEO收录号GSE277586获取。